Hal M Hoffman Selected Research

Proteins (Proteins, Gene)

1/2022	NOD-like receptor protein 3 activation causes spontaneous inflammation and fibrosis that mimics human NASH.
1/2020	ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model.
1/2019	NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice.
1/2019	Partial Jacobsen syndrome phenotype in a patient with a de novo frameshift mutation in the ETS1 transcription factor.
10/2017	Group A streptococcal M protein activates the NLRP3 inflammasome.
1/2017	Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis.
8/2015	The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.
10/2014	Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy.
10/2014	NLRP3 inflammasome activation is required for fibrosis development in NAFLD.
2/2012	Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.

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Hal M Hoffman Research Topics

Disease

36	Inflammation (Inflammations) 01/2022 - 11/2004
19	Cryopyrin-Associated Periodic Syndromes 01/2022 - 11/2004
9	Fibrosis (Cirrhosis) 01/2022 - 03/2014
9	Infections 01/2021 - 12/2010
6	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 10/2014
4	Non-alcoholic Fatty Liver Disease 01/2022 - 02/2012
4	Liver Diseases (Liver Disease) 01/2022 - 03/2014
4	Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) 10/2021 - 12/2015
4	Asthma (Bronchial Asthma) 10/2021 - 10/2012
4	Cachexia 10/2021 - 01/2020
3	Necrosis 01/2022 - 09/2007
3	Weight Gain 01/2021 - 01/2020
3	Rare Diseases (Rare Disease) 01/2019 - 09/2013
3	Fever (Fevers) 01/2018 - 07/2006
3	Airway Remodeling 11/2016 - 10/2012
3	Amyloidosis 04/2009 - 03/2007
2	Mevalonate Kinase Deficiency 01/2022 - 01/2018
2	Fatty Liver 01/2022 - 10/2014
2	Infantile Nephropathic Cystinosis 10/2021 - 01/2020
2	Chronic Renal Insufficiency 01/2021 - 01/2020
2	Familial Mediterranean Fever (Periodic Disease) 01/2018 - 09/2007
2	Urticaria (Hives) 06/2017 - 01/2007
2	Exanthema (Rash) 06/2017 - 01/2012
2	Respiratory Hypersensitivity 01/2017 - 11/2016
2	Obesity 03/2014 - 02/2012
1	Bites and Stings (Sting) 01/2022
1	Hypersensitivity (Allergy) 10/2021
1	Bacteremia 01/2021
1	Chronic Disease (Chronic Diseases) 01/2021
1	Infertility (Sterility) 01/2021
1	Congenital Heart Defects (Congenital Heart Defect) 01/2019
1	Jacobsen Distal 11q Deletion Syndrome 01/2019
1	Hereditary Autoinflammatory Diseases 01/2018
1	Rheumatoid Arthritis 01/2018
1	Arthritis (Polyarthritis) 01/2018
1	Body Weight (Weight, Body) 12/2017
1	Hearing Loss (Hearing Impairment) 12/2017
1	Splenomegaly 12/2017

Drug/Important Bio-Agent (IBA)

31	InflammasomesIBA 01/2022 - 01/2008
14	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2005
12	Interleukin-1 (Interleukin 1)IBA 01/2022 - 10/2006
8	CytokinesIBA 10/2021 - 08/2005
7	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 10/2021 - 10/2006
6	Interleukin-18 (Interleukin 18)IBA 12/2017 - 08/2005
5	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2022 - 11/2004
5	InterleukinsIBA 01/2022 - 03/2007
5	Interleukin-6 (Interleukin 6)IBA 01/2021 - 04/2007
4	LipopolysaccharidesIBA 01/2022 - 10/2009
4	AntigensIBA 11/2020 - 01/2015
3	NLR ProteinsIBA 01/2022 - 04/2015
3	Messenger RNA (mRNA)IBA 01/2019 - 10/2014
3	Serum Amyloid A Protein (Serum Amyloid A)IBA 06/2017 - 07/2006
3	C-Reactive ProteinIBA 06/2017 - 07/2006
3	Caspase 1 (ICE Protease)IBA 10/2014 - 08/2005
3	rilonacept FDA Link 10/2012 - 08/2008
2	Tamoxifen FDA LinkGeneric 01/2022 - 10/2014
2	Adenosine Triphosphate (ATP)IBA 01/2022 - 01/2020
2	Amino Acids FDA Link 01/2022 - 10/2014
2	Choline (Choline Chloride)IBA 01/2022 - 10/2014
2	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2019
2	Intravenous Immunoglobulins (IVIG)FDA Link 10/2021 - 02/2011
2	canakinumab FDA Link 01/2021 - 01/2018
2	Leucine (L-Leucine)FDA Link 01/2021 - 07/2010
2	Vitamin D FDA LinkGeneric 01/2020 - 01/2020
2	hydroxide ionIBA 01/2020 - 01/2020
2	Cathepsin BIBA 01/2019 - 09/2007
2	EnzymesIBA 01/2019 - 08/2005
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018 - 04/2007
2	Biological ProductsIBA 01/2018 - 07/2017
2	AllergensIBA 01/2017 - 04/2014
2	Orosomucoid (Seromucoid)IBA 04/2014 - 10/2012
2	Pharmaceutical PreparationsIBA 03/2014 - 10/2009
2	Uric Acid (Urate)IBA 09/2012 - 07/2010
2	LigandsIBA 12/2010 - 11/2010
1	Mitochondrial DNA (mtDNA)IBA 01/2022
1	CaspasesIBA 10/2021
1	NADPH Oxidases (NAD(P)H oxidase)IBA 10/2021
1	Monoclonal AntibodiesIBA 01/2021
1	Proline (L-Proline)FDA Link 01/2021
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2021
1	GS-444217IBA 01/2020
1	Calcitriol (Calcijex)FDA LinkGeneric 01/2020
1	Mitogen-Activated Protein KinasesIBA 01/2020
1	Mitochondrial Uncoupling ProteinsIBA 01/2020
1	MAP Kinase Kinase Kinase 5IBA 01/2020
1	Choline KinaseIBA 01/2019
1	ImmunosorbentsIBA 01/2019
1	Transcription Factors (Transcription Factor)IBA 01/2019
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019
1	Interleukin-17 (Interleukin 17)IBA 01/2018
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2018
1	Connective Tissue Growth FactorIBA 01/2018
1	Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA 01/2018
1	baricitinibIBA 01/2018
1	Colchicine FDA LinkGeneric 01/2018
1	Etanercept (Enbrel)FDA Link 12/2017
1	Tumor Necrosis Factor InhibitorsIBA 12/2017

Therapy/Procedure

13	Therapeutics 10/2021 - 07/2006
1	Aftercare (After-Treatment) 01/2021
1	Immunotherapy 01/2021